| First Author | Chen Z | Year | 2018 |
| Journal | J Immunol | Volume | 200 |
| Issue | 9 | Pages | 3117-3127 |
| PubMed ID | 29581354 | Mgi Jnum | J:261456 |
| Mgi Id | MGI:6155367 | Doi | 10.4049/jimmunol.1701026 |
| Citation | Chen Z, et al. (2018) Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses. J Immunol 200(9):3117-3127 |
| abstractText | Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKTFH) cells and their interactions with memory B cells in recall responses. Generation of memory iNKTFH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKTFH cells recognized lipid Ags presented by memory B cells, which recalled iNKTFH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags. |
