| First Author | Singh A | Year | 2023 |
| Journal | Front Immunol | Volume | 14 |
| Pages | 1067459 | PubMed ID | 36756127 |
| Mgi Jnum | J:335156 | Mgi Id | MGI:7433430 |
| Doi | 10.3389/fimmu.2023.1067459 | Citation | Singh A, et al. (2023) Transcription factor TFII-I fine tunes innate properties of B lymphocytes. Front Immunol 14:1067459 |
| abstractText | The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjogren's syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of Gtf2i in murine B lineage cells leads to an alteration in transcriptome, chromatin landscape and associated transcription factor binding sites, which exhibits myeloid-like features and coincides with enhanced sensitivity to LPS induced gene expression. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for GTF2I polymorphisms associated with B cell dominated autoimmune diseases in humans. |
