| First Author | Brioschi S | Year | 2021 |
| Journal | Science | Volume | 373 |
| Issue | 6553 | PubMed ID | 34083450 |
| Mgi Jnum | J:323381 | Mgi Id | MGI:6726650 |
| Doi | 10.1126/science.abf9277 | Citation | Brioschi S, et al. (2021) Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science |
| abstractText | The meninges contain adaptive immune cells that provide immunosurveillance of the CNS. These cells are thought to derive from the systemic circulation. Through single-cell analyses, confocal imaging, bone marrow chimeras, and parabiosis experiments, we show that meningeal B cells derive locally from the calvaria, which harbors a bone marrow niche for hematopoiesis. B cells reach the meninges from the calvaria through specialized vascular connections. This calvarial-meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens. Conversely, we show that a subset of antigen-experienced B cells that populate the meninges in aging mice are blood-borne. These results identify a private source for meningeal B cells. which may help maintain immune privilege within the CNS. |
