| First Author | Suzuki A | Year | 2003 |
| Journal | J Exp Med | Volume | 197 |
| Issue | 5 | Pages | 657-67 |
| PubMed ID | 12615906 | Mgi Jnum | J:91501 |
| Mgi Id | MGI:3047206 | Doi | 10.1084/jem.20021101 |
| Citation | Suzuki A, et al. (2003) Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med 197(5):657-67 |
| abstractText | Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell-specific mutation of Pten in mice (bPten(flox/flox)mice). bPten(flox/flox) mice showed elevated numbers of B1a cells and increased serum autoantibodies. Among B2 cells in bPten(flox/flox) spleens, numbers of marginal zone B (MZB) cells were significantly increased while those of follicular B (FOB) cells were correspondingly decreased. Pten-deficient B cells hyperproliferated, were resistant to apoptotic stimuli, and showed enhanced migration. The survival kinase PKB/Akt was highly activated in Pten-deficient splenic B cells. In addition, immunoglobulin class switch recombination was defective and induction of activation-induced cytidine deaminase (AID) was impaired. Thus, Pten plays a role in developmental fate determination of B cells and is an indispensable regulator of B cell homeostasis. |
