| First Author | Cantor J | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 4 | Pages | 412-9 |
| PubMed ID | 19270713 | Mgi Jnum | J:148000 |
| Mgi Id | MGI:3843136 | Doi | 10.1038/ni.1712 |
| Citation | Cantor J, et al. (2009) CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol 10(4):412-9 |
| abstractText | The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total suppression of B cell proliferation and subsequent plasma cell formation. Deletion of CD98hc did not impair early B cell activation but did inhibit later activation of the mitogen-activated protein kinase Erk1/2 and downregulation of the cell cycle inhibitor p27. Reconstitution of CD98hc-deficient B cells with CD98hc mutants showed that the integrin-binding domain of CD98hc was required for B cell proliferation but that the amino acid-transport function of CD98hc was dispensable for this. Thus, CD98hc supports integrin-dependent rapid proliferation of B cells. We propose that the advantage of adaptive immunity favored the appearance of CD98hc in vertebrates. |
