| First Author | Pelletier N | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 12 | Pages | 1110-8 |
| PubMed ID | 21037578 | Mgi Jnum | J:167325 |
| Mgi Id | MGI:4867801 | Doi | 10.1038/ni.1954 |
| Citation | Pelletier N, et al. (2010) Plasma cells negatively regulate the follicular helper T cell program. Nat Immunol 11(12):1110-8 |
| abstractText | B lymphocytes differentiate into antibody-secreting cells under the antigen-specific control of follicular helper T cells (T(FH) cells). Here we demonstrate that isotype-switched plasma cells expressed major histocompatibility complex (MHC) class II, the costimulatory molecules CD80 and CD86, and the intracellular machinery required for antigen presentation. Antigen-specific plasma cells accessed, processed and presented sufficient antigen in vivo to induce multiple helper T cell functions. Notably, antigen-primed plasma cells failed to induce interleukin 21 (IL-21) or the transcriptional repressor Bcl-6 in naive helper T cells and actively decreased these key molecules in antigen-activated T(FH) cells. Mice lacking plasma cells showed altered T(FH) cell activity, which provided evidence of this negative feedback loop. Hence, antigen presentation by plasma cells defines a previously unknown layer of cognate regulation that limits the antigen-specific T(FH) cell program that controls ongoing B cell immunity. |
