| First Author | Cox EM | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 4 | Pages | 112378 |
| PubMed ID | 37060566 | Mgi Jnum | J:353346 |
| Mgi Id | MGI:7470606 | Doi | 10.1016/j.celrep.2023.112378 |
| Citation | Cox EM, et al. (2023) AKT activity orchestrates marginal zone B cell development in mice and humans. Cell Rep 42(4):112378 |
| abstractText | The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cells or abolish its impact on FoxO transcription factors highlight the AKT-FoxO axis as an on-off switch for MZ B cell formation in mice. In humans, splenic immunoglobulin (Ig) D(+)CD27(+) B cells, proposed as an MZ B cell equivalent, display higher AKT signaling than naive IgD(+)CD27(-) and memory IgD(-)CD27(+) B cells and develop in an AKT-dependent manner from their precursors in vitro, underlining the conservation of this developmental pathway. Consistently, CD148 is identified as a receptor indicative of the level of AKT signaling in B cells, expressed at a higher level in MZ B cells than FO B cells in mice as well as humans. |
