| First Author | Yamamoto M | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 9 | Pages | 962-70 |
| PubMed ID | 16862162 | Mgi Jnum | J:112287 |
| Mgi Id | MGI:3655972 | Doi | 10.1038/ni1367 |
| Citation | Yamamoto M, et al. (2006) Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol 7(9):962-70 |
| abstractText | The Ubc13 E2 ubiquitin-conjugating enzyme is key in the process of 'tagging' target proteins with lysine 63-linked polyubiquitin chains, which are essential for the transmission of immune receptor signals culminating in activation of the transcription factor NF-kappaB. Here we demonstrate that conditional ablation of Ubc13 resulted in defective B cell development and in impaired B cell and macrophage activation. In response to all tested stimuli except tumor necrosis factor, Ubc13-deficient cells showed almost normal NF-kappaB activation but considerably impaired activation of mitogen-activated protein kinase. Ubc13-induced activation of mitogen-activated protein kinase required, at least in part, ubiquitination of the adaptor protein IKKgamma. These results show that Ubc13 is key in the mammalian immune response. |
