| First Author | Sin SH | Year | 2010 |
| Journal | J Virol | Volume | 84 |
| Issue | 20 | Pages | 10653-60 |
| PubMed ID | 20686032 | Mgi Jnum | J:164589 |
| Mgi Id | MGI:4834703 | Doi | 10.1128/JVI.00848-10 |
| Citation | Sin SH, et al. (2010) The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo. J Virol 84(20):10653-60 |
| abstractText | Gammaherpesviruses, including Kaposi sarcoma-associated herpesvirus (KSHV), establish latency in B cells. We hypothesized that the KSHV latency-associated nuclear antigen (LANA/orf73) provides a selective advantage to infected B cells by driving proliferation in response to antigen. To test this, we used LANA B-cell transgenic mice. Eight days after immunization with antigen without adjuvant, LANA mice had significantly more activated germinal center (GC) B cells (CD19(+) PNA(+) CD71(+)) than controls. This was dependent upon B-cell receptor since LANA did not restore the GC defect of CD19 knockout mice. However, LANA was able to restore the marginal zone defect in CD19 knockout mice. |
