| First Author | Qi CF | Year | 2013 |
| Journal | Leuk Res | Volume | 37 |
| Issue | 12 | Pages | 1680-9 |
| PubMed ID | 24199708 | Mgi Jnum | J:315870 |
| Mgi Id | MGI:6832332 | Doi | 10.1016/j.leukres.2013.09.009 |
| Citation | Qi CF, et al. (2013) Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC. Leuk Res 37(12):1680-9 |
| abstractText | The E3 ligase ARF-BP1 governs the balance of life and death decisions by directing the degradation of p53 and enhancing the transcriptional activity of MYC. We find B cells selectively deficient in ARF-BP1 have many defects in developing and mature B cells associated with increased expression of p53 and reduced expression of Myc. Overexpression of Myc results in suppression of p53 and complete reversal of defects induced by ARF-BP1 deficiency. These findings indicate that the dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1. |
