| First Author | Chakraborty M | Year | 2024 |
| Journal | J Immunol | Volume | 212 |
| Issue | 7 | Pages | 1075-1080 |
| PubMed ID | 38363205 | Mgi Jnum | J:347714 |
| Mgi Id | MGI:7625907 | Doi | 10.4049/jimmunol.2300336 |
| Citation | Chakraborty M, et al. (2024) Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells. J Immunol 212(7):1075-1080 |
| abstractText | B cell trafficking involves the coordinated activity of multiple adhesive and cytokine-receptor interactions, and the players in this process are not fully understood. In this study, we identified the tetraspanin CD53 as a critical regulator of both normal and malignant B cell trafficking. CXCL12 is a key chemokine in B cell homing to the bone marrow and secondary lymphoid organs, and both normal and malignant B cells from Cd53-/- mice have reduced migration toward CXCL12 in vitro, as well as impaired marrow homing in vivo. Using proximity ligation studies, we identified the CXCL12 receptor, CXCR4, as a novel, to our knowledge, CD53 binding partner. This interaction promotes receptor function, because Cd53-/- B cells display reduced signaling and internalization of CXCR4 in response to CXCL12. Together, our data suggest that CD53 interacts with CXCR4 on both normal and malignant B cells to promote CXCL12 signaling, receptor internalization, and marrow homing. |
