| First Author | Chen J | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 7 | Pages | 1890-6 |
| PubMed ID | 20449867 | Mgi Jnum | J:165926 |
| Mgi Id | MGI:4838935 | Doi | 10.1002/eji.200939817 |
| Citation | Chen J, et al. (2010) Foxo1 regulates marginal zone B-cell development. Eur J Immunol 40(7):1890-6 |
| abstractText | A fundamental component of signaling initiated by the BCR and CD19 is the activation of phosphoinositide 3-kinase. Downstream of phosphoinositide 3-kinase, the protein kinase AKT phosphorylates several substrates, including members of the forkhead box subgroup O (Foxo) transcription factor family. Among the Foxo proteins, Foxo1 has unique functions in bone marrow B-cell development and peripheral B-cell function. Here, we report a previously unrecognized role for Foxo1 in controlling the ratio of mature B-cell subsets in the spleen. Conditional deletion of Foxo1 in B cells resulted in an increased percentage of marginal zone B cells and a decrease in follicular (FO) B cells. In addition, Foxo1 deficiency corrected the absence of marginal zone B cells that occurs in CD19-deficient mice. These findings show that Foxo1 regulates the balance of mature B-cell subsets and is required for the marginal zone B-cell deficiency phenotype of mice lacking CD19. |
