| First Author | Ye X | Year | 2008 |
| Journal | Biol Reprod | Volume | 79 |
| Issue | 2 | Pages | 328-36 |
| PubMed ID | 18448840 | Mgi Jnum | J:140799 |
| Mgi Id | MGI:3814638 | Doi | 10.1095/biolreprod.108.068783 |
| Citation | Ye X, et al. (2008) Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling. Biol Reprod 79(2):328-36 |
| abstractText | Approximately half of all infertility cases can be attributed to male reproductive dysfunction for which low sperm count is a major contributing factor. The current study identified receptor-mediated lysophosphatidic acid (LPA) signaling as a new molecular component influencing male fertility. LPA is a small signaling phospholipid, the effects of which are mediated through at least five G protein-coupled receptors, named LPA 1-5. LPA1/2/3, but not LPA4/5, show high expression in mouse testis. Mice deficient in LPA1/2/3 showed a testosterone-independent reduction of mating activity and sperm production, with an increased prevalence of azoospermia in aging animals. A significant increase of germ cell apoptosis also was observed in testes. Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis. |
