| First Author | Azoulay-Cayla A | Year | 2000 |
| Journal | J Virol | Volume | 74 |
| Issue | 12 | Pages | 5470-6 |
| PubMed ID | 10823851 | Mgi Jnum | J:62300 |
| Mgi Id | MGI:1858693 | Doi | 10.1128/jvi.74.12.5470-5476.2000 |
| Citation | Azoulay-Cayla A, et al. (2000) H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virus. J Virol 74(12):5470-6 |
| abstractText | H-2(b) mice are resistant to persistent infection of the central nervous system by Theiler's virus. They clear the infection 7 to 10 days after intracranial inoculation. Resistance maps to the H-2D gene and not to the H-2K gene and is associated with a potent antiviral cytotoxic T-lymphocyte (CTL) response. We used H-2(b) mice in which the H-2D or the H-2K gene had been inactivated to dissect the respective roles of these genes in resistance. We report that H-2D(-/-) but not H-2K(-/-) mice were susceptible to persistent infection. Furthermore, whereas H-2K(-/-) mice mounted a vigorous virus-specific CTL response, similar to that of control C57BL/6 mice, the CTL response of H-2D(-/-) mice was nil or minimal. Using target cells transfected with the H-2D(b) or the H-2K(b) gene, we showed that the H-2K-restricted CTL response against the virus was minimal in H-2D(-/-) mice. These results demonstrate that the H-2D(b) and H-2K(b) genes play nonredundant roles in the resistance to this persistent infection. |
