| First Author | Schildknecht A | Year | 2009 |
| Journal | Eur J Immunol | Volume | 39 |
| Issue | 6 | Pages | 1505-15 |
| PubMed ID | 19462379 | Mgi Jnum | J:149527 |
| Mgi Id | MGI:3848641 | Doi | 10.1002/eji.200839019 |
| Citation | Schildknecht A, et al. (2009) Antigens expressed by myelinating glia cells induce peripheral cross-tolerance of endogenous CD8+ T cells. Eur J Immunol 39(6):1505-15 |
| abstractText | Auto-reactivity of T cells is largely prevented by central and peripheral tolerance. Nevertheless, immunization with certain self-antigens emulsified in CFA induces autoimmunity in rodents, suggesting that tolerance to some self-antigens is not robust. To investigate the fate of nervous system-specific CD8(+) T cells, which only recently came up as being important contributors for MS pathogenesis, we developed a mouse model that allows inducible expression of lymphocytic choriomeningitis virus-derived CD8(+) T-cell epitopes specifically in oligodendrocytes and Schwann cells, the myelinating glia of the nervous system. These transgenic CD8(+) T-cell epitopes induced robust tolerance of endogenous auto-reactive T cells, which proved thymus-independent and was mediated by cross-presenting bone-marrow-derived cells. Immunohistological staining of secondary lymphoid organs demonstrated the presence of glia-derived antigens in DC, suggesting that peripheral tolerance of CD8(+) T cells results from uptake and presentation by steady state DC. |
