| First Author | Won WJ | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 1 | Pages | 230-7 |
| PubMed ID | 18097024 | Mgi Jnum | J:130897 |
| Mgi Id | MGI:3772518 | Doi | 10.4049/jimmunol.180.1.230 |
| Citation | Won WJ, et al. (2008) CD36 is differentially expressed on B cell subsets during development and in responses to antigen. J Immunol 180(1):230-7 |
| abstractText | Of a number of mAbs made by immunization with sort-purified marginal zone (MZ) B cells, one was shown to recognize the mouse scavenger receptor CD36. Although CD36 is expressed by most resting MZ B cells and not by follicular and B1 B cells, it is rapidly induced on follicular B cells in vitro following TLR and CD40 stimulation. In response to T-independent and T-dependent Ag challenge, we found that CD36 was expressed on IgM+ plasma cells, but down-regulated on isotype-switched plasma cells in vivo. Although development, localization, and phenotype of MZ B cells in CD36-/- mice appeared normal, there was a minor block in the transitional stages of mature B cell development. In both primary and secondary Ab responses to heat-killed Streptococcus pneumoniae (R36A strain), both phosphoryl choline (PC)-specific IgM and IgG levels in CD36-/- mice were slightly reduced compared with wild-type mice. In addition, mice deficient in both TLR2 and CD36 produced significantly reduced levels of anti-PC IgG titers than those of single gene-deficient mice, suggesting that they may cooperate in an anti-PC Ab response. Collectively, these results show that CD36 does not affect the development of B cells, but modulates both primary and secondary anti-PC Ab responses during S. pneumoniae infection similarly to TLR2. |
