| First Author | Kim U | Year | 2000 |
| Journal | J Immunol | Volume | 165 |
| Issue | 12 | Pages | 6825-32 |
| PubMed ID | 11120805 | Mgi Jnum | J:66173 |
| Mgi Id | MGI:1928057 | Doi | 10.4049/jimmunol.165.12.6825 |
| Citation | Kim U, et al. (2000) Genetic analyses of NFKB1 and OCA-B function: defects in B cells, serum IgM level, and antibody responses in Nfkb1(-/-)Oca-b(-/-) mice. J Immunol 165(12):6825-32 |
| abstractText | Defined patterns of gene expression during cell differentiation are likely to be ensured by multiple factors playing redundant roles. By generating mice deficient in both NFKB1 and OCA-B, we show here that the two transcription factors are required for B-1 cell differentiation and serum IgM production. In addition, relative to Nfkb1(-/-) or Oca-b(-/-) mice, the Nfkb1(-/-)Oca-b(-/-) mice show a decrease in conventional B cell frequencies in the spleen and augmented reductions in T-independent and T-dependent Ab responses. These results suggest that NFKB1 and OCA-B play compensatory roles in multiple aspects of B cell differentiation. |
