| First Author | Siegel R | Year | 2006 |
| Journal | Cell | Volume | 125 |
| Issue | 4 | Pages | 761-74 |
| PubMed ID | 16713566 | Mgi Jnum | J:114816 |
| Mgi Id | MGI:3690194 | Doi | 10.1016/j.cell.2006.03.036 |
| Citation | Siegel R, et al. (2006) Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development. Cell 125(4):761-74 |
| abstractText | OCA-B was originally identified as a nuclear transcriptional coactivator that is essential for antigen-driven immune responses. The later identification of a membrane bound, myristoylated form of OCA-B suggested additional, unique functions in B cell signaling pathways. This study has shown that OCA-B also functions in the pre-B1-to-pre-B2 cell transition and, most surprisingly, that it directly interacts with SYK, a tyrosine kinase critical for pre-BCR and BCR signaling. This unprecedented type of interaction-a transcriptional coactivator with a signaling kinase-occurs in the cytoplasm and directly regulates SYK stability. This study indicates that OCA-B is required for pre-BCR and BCR signaling at multiple stages of B cell development through its nontranscriptional regulation of SYK. Combined with the deregulation of OCA-B target genes, this may help explain the multitude of defects observed in B cell development and immune responses of Oca-b-/- mice. |
