| First Author | Harada T | Year | 1998 |
| Journal | Proc Natl Acad Sci U S A | Volume | 95 |
| Issue | 8 | Pages | 4663-6 |
| PubMed ID | 9539795 | Mgi Jnum | J:47463 |
| Mgi Id | MGI:1203466 | Doi | 10.1073/pnas.95.8.4663 |
| Citation | Harada T, et al. (1998) Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci U S A 95(8):4663-6 |
| abstractText | In the retina, the glutamate transporter GLAST is expressed in Muller and various types of bipolar cells. To investigate the functional role of this differential distribution of glutamate transporters, we have analyzed GLAST and GLT-1 mutant mice. In GLAST-deficient mice, the electroretinogram b-wave and oscillatory potentials are reduced and retinal damage after ischemia is exacerbated, whereas GLT-1-deficient mice show almost normal electroretinograms and mild increased retinal damage after ischemia. These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina. |
