| First Author | Haas KM | Year | 2002 |
| Journal | Immunity | Volume | 17 |
| Issue | 6 | Pages | 713-23 |
| PubMed ID | 12479818 | Mgi Jnum | J:95979 |
| Mgi Id | MGI:3528518 | Doi | 10.1016/s1074-7613(02)00483-1 |
| Citation | Haas KM, et al. (2002) Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. Immunity 17(6):713-23 |
| abstractText | The CD21/35 receptor provides an important link between innate and adaptive immunity. Its importance during protective immune responses to encapsulated extracellular bacteria was assessed using a new line of mice completely deficient in CD21/35 expression (CD21/35(-/-)). CD21/35 expression was essential for the rapid trapping of C3dg-antigen complexes by B cells in vivo, especially in splenic marginal zones. Despite normal B cell development in CD21/35(-/-) mice, T cell-independent and -dependent antibody responses to low-dose antigens were significantly decreased, with a striking impairment in IgG3 responses. Accordingly, CD21/35(-/-) mice were more susceptible to acute lethal Streptococcus pneumoniae infection. Thus, CD21/35 expression is critical for early protective antibody responses to lethal pathogens that rapidly multiply and quickly overwhelm the immune system. |
