| First Author | Prodeus AP | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 5 | Pages | 721-31 |
| PubMed ID | 9846493 | Mgi Jnum | J:51357 |
| Mgi Id | MGI:1315137 | Doi | 10.1016/s1074-7613(00)80669-x |
| Citation | Prodeus AP, et al. (1998) A critical role for complement in maintenance of self-tolerance. Immunity 9(5):721-31 |
| abstractText | The role of complement in the maintenance of self-tolerance has been examined in two models: an immunoglobulin transgenic model of peripheral tolerance and a lupus-like murine model of CD95 (Fas) deficiency. We find that self-reactive B lymphocytes deficient in complement receptors CD21/CD35 or transferred into mice deficient in the complement protein C4 are not anergized by soluble self-antigen. In the second model, deficiency in CD21/CD35 or C4 combined with CD95 deficiency results in high titers of anti-nuclear antibodies leading to severe lupus-like disease. These findings suggest a novel role for the complement system in B cell tolerance and provide insight into the genetic association of complement deficiency with susceptibility to systemic lupus erythematosus. |
