| First Author | Bradl H | Year | 2004 |
| Journal | Immunol Lett | Volume | 95 |
| Issue | 1 | Pages | 71-5 |
| PubMed ID | 15325800 | Mgi Jnum | J:110964 |
| Mgi Id | MGI:3652457 | Doi | 10.1016/j.imlet.2004.06.004 |
| Citation | Bradl H, et al. (2004) CD44 is dispensable for B lymphopoiesis. Immunol Lett 95(1):71-5 |
| abstractText | Several studies have implicated a role for the cell surface glycoprotein CD44 in lymphocyte differentiation, adhesion to the matrix, homing, activation and apoptosis. However, the requirement of CD44 in B cell maturation remains elusive. To address this point, we analyzed the generation and activation of B lymphocytes in CD44-deficient mice. Unexpectedly, both maturation and autoreconstitution of early bone marrow B cell progenitors after sublethal irradiation as well as frequencies of splenic B cell subsets are indistinguishable in wild-type and CD44-deficient mice. Furthermore, splenic CD44-deficient B lymphocytes show a normal activation pattern after stimulation with LPS, anti-IgM/IL-4 or anti-CD40/IL-4. These results show for the first time that CD44 is clearly dispensable for development, reconstitution and activation of B lymphocytes. |
