| First Author | Ma Q | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 4 | Pages | 463-71 |
| PubMed ID | 10229189 | Mgi Jnum | J:110532 |
| Mgi Id | MGI:3640454 | Doi | 10.1016/s1074-7613(00)80046-1 |
| Citation | Ma Q, et al. (1999) The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 10(4):463-71 |
| abstractText | We report that the chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within fetal liver and bone marrow microenvironment. In CXCR4-deficient embryos, pro-B cells are present in blood but hardly detectable in liver; myeloid cells are elevated in blood and reduced in liver compared to wild-type embryos. Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor-derived mature B lymphocytes in blood and lymphoid organs. The numbers of pro-B and pre-B cells are reduced in bone marrow and abnormally high in blood. Granulocytic cells are reduced in bone marrow but elevated and less mature in the blood. B lineage and granulocytic precursors are released into the periphery in absence of CXCR4. |
