| First Author | Wang Q | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 4 | Pages | 697-708 |
| PubMed ID | 8929538 | Mgi Jnum | J:36593 |
| Mgi Id | MGI:84021 | Doi | 10.1016/s0092-8674(00)81389-6 |
| Citation | Wang Q, et al. (1996) The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 87(4):697-708 |
| abstractText | The CBF beta subunit is the non-DNA-binding subunit of the heterodimeric core-binding factor (CBF). CBF beta associates with DNA-binding CBF alpha subunits and increases their affinity for DNA. Genes encoding the CBF beta subunit (CBFB) and one of the CBF alpha subunits (CBFA2, otherwise known as AML1) are the most frequent targets of chromosomal translocations in acute leukemias in humans. We and others previously demonstrated that homozygous disruption of the mouse Cbfa2 (AML1) gene results in embryonic lethality at midgestation due to hemorrhaging in the central nervous system and blocks fetal liver hematopoiesis. Here we demonstrate that homozygous mutation of the Cbfb gene results in the same phenotype. Our results demonstrate that the CBF beta subunit is required for CBF alpha 2 function in vivo. |
