| First Author | Guo Y | Year | 2008 |
| Journal | Blood | Volume | 112 |
| Issue | 3 | Pages | 480-92 |
| PubMed ID | 18390836 | Mgi Jnum | J:138457 |
| Mgi Id | MGI:3805179 | Doi | 10.1182/blood-2007-10-120261 |
| Citation | Guo Y, et al. (2008) Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification. Blood 112(3):480-92 |
| abstractText | CBFbeta is the non-DNA binding subunit of the core binding factors (CBFs). Mice with reduced CBFbeta levels display profound, early defects in T-cell but not B-cell development. Here we show that CBFbeta is also required at very early stages of natural killer (NK)-cell development. We also demonstrate that T-cell development aborts during specification, as the expression of Gata3 and Tcf7, which encode key regulators of T lineage specification, is substantially reduced, as are functional thymic progenitors. Constitutively active Notch or IL-7 signaling cannot restore T-cell expansion or differentiation of CBFbeta insufficient cells, nor can overexpression of Runx1 or CBFbeta overcome a lack of Notch signaling. Therefore, the ability of the prethymic cell to respond appropriately to Notch is dependent on CBFbeta, and both signals converge to activate the T-cell developmental program. |
