| First Author | Chalasani SH | Year | 2003 |
| Journal | J Neurosci | Volume | 23 |
| Issue | 11 | Pages | 4601-12 |
| PubMed ID | 12805300 | Mgi Jnum | J:123817 |
| Mgi Id | MGI:3719727 | Doi | 10.1523/JNEUROSCI.23-11-04601.2003 |
| Citation | Chalasani SH, et al. (2003) The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. J Neurosci 23(11):4601-12 |
| abstractText | The chemokine receptor CXCR4 is expressed in the embryonic and mature CNS, yet its normal physiological function in neurons remains obscure. Here, we show that its cognate chemokine, stromal cell-derived factor-1 (SDF-1), promotes the survival of cultured embryonic retinal ganglion cell neurons even in the absence of other neurotrophic factors. This survival effect is mediated primarily through a cAMP-dependent pathway that acts through protein kinase A and MAP kinase. Addition of SDF-1 to a human neuronal cell line induces phosphorylation of p44/p42 MAP kinase and GSK3beta. Mouse embryos lacking the CXCR4 receptor have a reduced number of retinal ganglion cells. The ligand of CXCR4, SDF-1, may therefore provide generalized trophic support to neurons during their development and maturation. |
