| First Author | Kiu H | Year | 2009 |
| Journal | Growth Factors | Volume | 27 |
| Issue | 6 | Pages | 384-93 |
| PubMed ID | 19919527 | Mgi Jnum | J:191784 |
| Mgi Id | MGI:5463112 | Doi | 10.3109/08977190903210954 |
| Citation | Kiu H, et al. (2009) Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. Growth Factors 27(6):384-93 |
| abstractText | Suppressor of cytokine signalling (SOCS) 3 is an essential regulator of cytokine signalling, and in turn its expression is tightly regulated. Data from overexpression studies in cell lines suggest that SOCS2 regulates SOCS3 protein degradation, by forming a molecular bridge to an E3 ubiquitin-ligase complex. Whether this regulation is relevant in primary cells is unknown. In this study, we utilized Socs2( - / - ) mice to examine the role of SOCS2 in modulating SOCS3 expression and degradation, and its impact on interleukin-2 (IL-2) and IL-6 signalling in primary haemopoietic cells. Both biochemical and biological analyses demonstrated unperturbed SOCS3 expression and cytokine signalling in the absence of SOCS2. Our results suggest that SOCS2 is not a physiological regulator of SOCS3 expression and action in primary haemopoietic cells. |
