| Primary Identifier | MGI:1934621 | Allele Type | Chemically induced (ENU) |
| Gene | Pax6 | Inheritance Mode | Not Specified |
| Strain of Origin | BALB/cAnN | Is Recombinase | false |
| Is Wild Type | false |
| description | The phenotype in the Pax6Leca allelic series (Leca 1-4) produced a range of similar but variable eye phenotypes, with slightly smaller eyes and occasional adhensions between the lens and cornea. ENU-treated BALB/cAnN male mice were mated to wild-type C3H/HeN females and their F1 progeny screened for eye and vision defects. (J:75964) |
| molecularNote | The mutation underlying the phenotype in Leca2 mice was identified as a C to T substitution at nucleotide position 586 of the Pax6 gene. The mutation occurs in exon 7 and introduces the Arg142Cys change in the Paired box domain of the protein. |
