| First Author | Köchl R | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 9 | Pages | 1075-83 |
| PubMed ID | 27400149 | Mgi Jnum | J:259583 |
| Mgi Id | MGI:6141968 | Doi | 10.1038/ni.3495 |
| Citation | Kochl R, et al. (2016) WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol 17(9):1075-83 |
| abstractText | Adhesion and migration of T cells are controlled by chemokines and by adhesion molecules, especially integrins, and have critical roles in the normal physiological function of T lymphocytes. Using an RNA-mediated interference screen, we identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration. We found that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2. WNK1-deficient T cells home less efficiently to lymphoid organs and migrate more slowly through them. Our results reveal that a pathway previously known only to regulate salt homeostasis in the kidney functions to balance T cell adhesion and migration. |
