| First Author | Pradel LC | Year | 2009 |
| Journal | Eur J Immunol | Volume | 39 |
| Issue | 8 | Pages | 2270-80 |
| PubMed ID | 19609977 | Mgi Jnum | J:151985 |
| Mgi Id | MGI:4355655 | Doi | 10.1002/eji.200838867 |
| Citation | Pradel LC, et al. (2009) ATP-binding cassette transporter hallmarks tissue macrophages and modulates cytokine-triggered polarization programs. Eur J Immunol 39(8):2270-80 |
| abstractText | Macrophages are central players in both lipid metabolism and innate immunity. Their determinant role in the pathogenesis of atherosclerosis is under the control of the ATP-binding cassette transporter (ABCA1), which by minimizing cellular lipid content, limits development of pro-inflammatory foam cells. Considering the differential contribution of monocyte subsets to the generation of vascular lesions we analyzed the immunophenotype of ABCA1-expressing cells in the myeloid lineage, by the combined use of flow cytometry and real-time quantitative RT-PCR. ABCA1 expression is limited to 'non-inflammatory' Ly6C(lo) circulating monocytes and tissue-resident macrophages expressing markers of alternative activation. In ABCA1(-/-) peritoneal macrophages the transcriptional programs induced by LPS/IFN-gamma or IL-4 cytokines are altered and deviated phosphorylation patterns of STAT transcriptional regulators in response to stimuli are observed. |
