| First Author | Lam DD | Year | 2011 |
| Journal | Cell Metab | Volume | 13 |
| Issue | 5 | Pages | 584-91 |
| PubMed ID | 21531340 | Mgi Jnum | J:175812 |
| Mgi Id | MGI:5287346 | Doi | 10.1016/j.cmet.2011.03.016 |
| Citation | Lam DD, et al. (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab 13(5):584-91 |
| abstractText | Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not express LepRb. Indeed, while leptin hyperpolarizes some non-5-HT DR neurons, leptin does not alter the activity of DR 5-HT neurons. Furthermore, 5-HT depletion does not impair the anorectic effects of leptin. The serotonin transporter-cre allele (Sert(cre)) is expressed in 5-HT (and developmentally in some non-5-HT) neurons. While Sert(cre) promotes LepRb excision in a few LepRb neurons in the hypothalamus, it is not active in DR LepRb neurons, and neuron-specific Sert(cre)-mediated LepRb inactivation in mice does not alter body weight or adiposity. Thus, leptin does not directly influence 5-HT neurons and does not meaningfully modulate important appetite-related determinants via 5-HT neuron function. |
