| First Author | Hishida T | Year | 2022 |
| Journal | Front Cell Dev Biol | Volume | 10 |
| Pages | 786031 | PubMed ID | 35309931 |
| Mgi Jnum | J:329157 | Mgi Id | MGI:7257186 |
| Doi | 10.3389/fcell.2022.786031 | Citation | Hishida T, et al. (2022) Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. Front Cell Dev Biol 10:786031 |
| abstractText | It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout-induced senescence, therefore suggesting that a mitochondrial superoxide takes part in inducing senescence. Taken together, these analyses reveal extremely low levels of cellular senescence and senescence-associated phenotypes in the esophageal epithelium, as well as a critical role for Myc in self-renewal of basal cells in this organ. This provides new avenues for studying and understanding the links between stemness and resistance to cellular senescence. |
