| First Author | Duan RS | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 183 |
| Issue | 1-2 | Pages | 162-7 |
| PubMed ID | 17218016 | Mgi Jnum | J:124505 |
| Mgi Id | MGI:3721780 | Doi | 10.1016/j.jneuroim.2006.12.001 |
| Citation | Duan RS, et al. (2007) IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis. J Neuroimmunol 183(1-2):162-7 |
| abstractText | IL-18 deficient (IL-18-/-) mice were used to investigate the role of IL-18 in the pathogenesis of experimental autoimmune neuritis (EAN) which was induced by immunization of the mice with P0 protein peptide 180-199. The clinical course was not different between IL-18-/- and wild-type mice. The splenic mononuclear cell (MNC) proliferation was also similar in both animal groups. However, the percentages of IFN-gamma, IL-10 and IL-12 positive cells were decreased among infiltrating MNC of cauda equine in IL-18-/- mice. This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN. |
