| First Author | Wang Q | Year | 2017 |
| Journal | Neuron | Volume | 96 |
| Issue | 5 | Pages | 1084-1098.e7 |
| PubMed ID | 29154130 | Mgi Jnum | J:256151 |
| Mgi Id | MGI:6114240 | Doi | 10.1016/j.neuron.2017.10.029 |
| Citation | Wang Q, et al. (2017) Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron 96(5):1084-1098.e7 |
| abstractText | Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor mediate homeostatic plasticity in cortical neurons. Sema3F-Npn-2/PlexA3 signaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in neuronal activity, Npn-2 associates with AMPARs, and Sema3F regulates this interaction. Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity. |
