| First Author | Fukamauchi F | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 221 |
| Issue | 1 | Pages | 151-6 |
| PubMed ID | 8660327 | Mgi Jnum | J:32517 |
| Mgi Id | MGI:80011 | Doi | 10.1006/bbrc.1996.0561 |
| Citation | Fukamauchi F, et al. (1996) Abnormal behavior and neurotransmissions of tenascin gene knockout mouse. Biochem Biophys Res Commun 221(1):151-6 |
| abstractText | To examine the role of tenascin (TN) in vivo, we have produced mice in which the TN gene is inactivated. In behavioral studies, TN-knockout mice showed abnormal behavior such as hyperlocomotion and poor swimming ability. Biochemical analysis revealed that serotonin (5-HT) and dopamine (DA) transmission was decreased in the cerebral cortex, the hippocampus, or the striatum of TN-knockout mouse brain. The intraperitoneal administration of the DA receptor agonist, LY171555 (0.5 mg/kg, BW), inhibited the hyperlocomotion, and swimming behavior was transiently improved by the treatment with the 5-HT receptor agonist, 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride. These findings suggest that TN may play an important role in neurotransmissions related to behavior. |
