First Author | Doan TC | Year | 2018 |
Journal | J Allergy Clin Immunol | Volume | 142 |
Issue | 2 | Pages | 695-698.e4 |
PubMed ID | 29705244 | Mgi Jnum | J:328894 |
Mgi Id | MGI:6869770 | Doi | 10.1016/j.jaci.2018.02.054 |
Citation | Doan TC, et al. (2018) Matrix protein tenascin-C expands and reversibly blocks maturation of murine eosinophil progenitors. J Allergy Clin Immunol 142(2):695-698.e4 |
abstractText | We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix's regulation of in situ hematopoiesis has significant implications for targeting tissue eosinophils. |