| First Author | Koyama Y | Year | 1998 |
| Journal | J Invest Dermatol | Volume | 111 |
| Issue | 6 | Pages | 930-5 |
| PubMed ID | 9856798 | Mgi Jnum | J:51408 |
| Mgi Id | MGI:1316589 | Doi | 10.1046/j.1523-1747.1998.00401.x |
| Citation | Koyama Y, et al. (1998) Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse. J Invest Dermatol 111(6):930-5 |
| abstractText | Tenascin-C is a large extracellular matrix glycoprotein characterized by its spatiotemporal expression during embryogenesis, carcinogenesis, and wound healing. Many in vitro studies on tenascin-C have revealed its multifunctional properties; however, disruption of the tenascin-C gene did not reveal any obvious abnormalities during development, and its function in vivo remains unclear. Here, we investigated whether tenascin-C is involved in inflammatory dermatitis in adults by studying chemically induced dermatitis in tenascin-C knockout mice. An epicutaneous application of a hapten, 2,4-dinitrofluorobenzene, to the ear skin of BALB/CA mice resulted in inflammation and induced the expression of tenascin-C. In congenic tenascin-C knockout mice, the dermatitis occurred more severely than in wild-type mice; infiltration of polymorphonuclear cells in knockout mice persisted longer than in wild-type mice, and the elastosis-like disorganized extracellular matrix was also seen in the ear. These results suggest that tenascin-C plays a role in vivo in inflammatory responses in the skin, and that the genetic background has profound effects on the function of tenascin-C in mouse dermatitis. |
