| First Author | Fukamauchi F | Year | 1997 |
| Journal | Eur J Pharmacol | Volume | 338 |
| Issue | 1 | Pages | 7-10 |
| PubMed ID | 9407997 | Mgi Jnum | J:44534 |
| Mgi Id | MGI:1100418 | Doi | 10.1016/s0014-2999(97)01298-3 |
| Citation | Fukamauchi F, et al. (1997) Paradoxical behavioral response to apomorphine in tenascin-gene knockout mouse. Eur J Pharmacol 338(1):7-10 |
| abstractText | Tenascin is a large extracellular matrix glycoprotein which is highly expressed in the developing nervous system. To examine the role of tenascin in vivo, we have produced mice in which the tenascin-gene is inactivated. These animals did not easily habituate to unfamiliar circumstances and displayed hyperlocomotion. A dopamine receptor agonist, apomorphine, reduced this hyperlocomotion dose dependently, but this phenomenon was not due to the appearance of apomorphine-induced stereotypic behavior, suggesting that tenascin-gene mutant mice have a paradoxical behavioral response to apomorphine compared to wild-type mice. |
