| First Author | Brellier F | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 6 | Pages | 913-20 |
| PubMed ID | 21354146 | Mgi Jnum | J:170702 |
| Mgi Id | MGI:4947164 | Doi | 10.1016/j.febslet.2011.02.023 |
| Citation | Brellier F, et al. (2011) Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator. FEBS Lett 585(6):913-20 |
| abstractText | We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression. Transcript profiling analysis identified tissue plasminogen activator (tPA) as the most consistently over-expressed gene in all tenascin-C deficient MEFs. This was confirmed by real-time PCR as well as by protein expression analysis. In agreement with these observations, tenascin-C deficient MEFs had an increased capacity to digest fibrin in situ. Consistently, tenascin-C expression in vivo was found to correlate with fibrin deposition in several diseases associated with tenascin-C overexpression such as fibrosis, asthma and cancer. In conclusion, the present study suggests a new role of tenascin-C as a regulator of the fibrinolytic system. |
