| First Author | Schliselfeld LH | Year | 2002 |
| Journal | Biochem Biophys Res Commun | Volume | 290 |
| Issue | 2 | Pages | 874-7 |
| PubMed ID | 11785984 | Mgi Jnum | J:73924 |
| Mgi Id | MGI:2157196 | Doi | 10.1006/bbrc.2001.6292 |
| Citation | Schliselfeld LH, et al. (2002) Inverse relationship of skeletal muscle glycogen from wild-type and genetically modified mice to their phosphorylase a activity. Biochem Biophys Res Commun 290(2):874-7 |
| abstractText | Leg muscle was biopsied and frozen for storage at -70 degrees C. from 5 wild-type mice, two knocked out acid alpha-glucosidase (GAA) gene mice, and seven glycogen synthase plus glucose muscle transporter transgenic mice. All of the wild-type mice had very little muscle glycogen (3.58 +/- 1.67 micromols glucosyl subunits per g muscle), and 52% or more of its glycogen phosphorylase activity without AMP (69% +/- 17% glycogen phosphorylase a). In contrast the GAA knockout and transgenic mice had glycogen ranging from 63 to 297 micromols glucosyl subunits per g muscle, and very little or no glycogen phosphorylase activity without 1.00 mM AMP (4.8% and less glycogen phosphorylase a). This suggests that there is an inverse relationship between mouse muscle phosphorylase a and the muscle's glycogen content. |
