| First Author | Zhao C | Year | 2007 |
| Journal | Cancer Cell | Volume | 12 |
| Issue | 6 | Pages | 528-41 |
| PubMed ID | 18068630 | Mgi Jnum | J:130324 |
| Mgi Id | MGI:3771482 | Doi | 10.1016/j.ccr.2007.11.003 |
| Citation | Zhao C, et al. (2007) Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 12(6):528-41 |
| abstractText | A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells. Here we show that beta-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance. Moreover, beta-catenin deletion causes a profound reduction in the ability of mice to develop BCR-ABL-induced chronic myelogenous leukemia (CML), while allowing progression of acute lymphocytic leukemia (ALL). These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system. |
