| First Author | Gulacsi AA | Year | 2008 |
| Journal | Nat Neurosci | Volume | 11 |
| Issue | 12 | Pages | 1383-91 |
| PubMed ID | 18997789 | Mgi Jnum | J:145017 |
| Mgi Id | MGI:3833176 | Doi | 10.1038/nn.2226 |
| Citation | Gulacsi AA, et al. (2008) Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon. Nat Neurosci 11(12):1383-91 |
| abstractText | Development of the telencephalon involves the coordinated growth of diversely patterned brain structures. Previous studies have demonstrated the importance of beta-catenin-mediated Wnt signaling in proliferation and fate determination during cerebral cortical development. We found that beta-catenin-mediated Wnt signaling critically maintained progenitor proliferation in the subcortical (pallidal) telencephalon. Targeted deletion of beta-catenin in mice severely impaired proliferation in the medial ganglionic eminence without grossly altering differentiated fate. Several lines of evidence suggest that this phenotype is primarily the result of a loss of canonical Wnt signaling. As previous studies have suggested that the ventral patterning factor Sonic Hedgehog (Shh) also stimulates dorsal telencephalic proliferation, we propose a model whereby Wnt and Shh signaling promote distinct dorsal-ventral patterning while also having broader effects on proliferation that serve to coordinate the growth of telencephalic subregions. |
