| First Author | Mutch CA | Year | 2009 |
| Journal | J Neurosci | Volume | 29 |
| Issue | 43 | Pages | 13710-9 |
| PubMed ID | 19864583 | Mgi Jnum | J:158308 |
| Mgi Id | MGI:4438530 | Doi | 10.1523/JNEUROSCI.3022-09.2009 |
| Citation | Mutch CA, et al. (2009) Beta-catenin signaling levels in progenitors influence the laminar cell fates of projection neurons. J Neurosci 29(43):13710-9 |
| abstractText | The mechanisms underlying the timing of the laminar fate decisions during cortical neurogenesis remain poorly understood. Here we show that beta-catenin signaling in cortical neural precursors can regulate the laminar fate of their daughters. In ventricular zone neural precursors, beta-catenin signaling is higher when deep-layer neurons are being generated and lower when upper-layer neurons are being generated. Overactivation of beta-catenin in cortical precursors midway through corticogenesis increased the relative production of deep-layer neurons, while inhibition of signaling increased the relative production of upper-layer neurons. Furthermore, in late-gestation upper-layer precursors, overactive beta-catenin signaling was able to partially restore production of deep-layer neurons. These observations suggest that increased beta-catenin signaling can reset the timing of cortical precursors to promote the production of deep-layer neurons, while inhibition of beta-catenin signaling advances the timing to promote upper-layer production. |
