| First Author | Dias C | Year | 2014 |
| Journal | Nature | Volume | 516 |
| Issue | 7529 | Pages | 51-5 |
| PubMed ID | 25383518 | Mgi Jnum | J:217477 |
| Mgi Id | MGI:5614154 | Doi | 10.1038/nature13976 |
| Citation | Dias C, et al. (2014) beta-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature 516(7529):51-5 |
| abstractText | beta-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice beta-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide beta-catenin enrichment mapping, we identify Dicer1-important in small RNA (for example, microRNA) biogenesis--as a beta-catenin target gene that mediates resilience. Small RNA profiling after excising beta-catenin from nucleus accumbens in the context of chronic stress reveals beta-catenin-dependent microRNA regulation associated with resilience. Together, these findings establish beta-catenin as a critical regulator in the development of behavioural resilience, activating a network that includes Dicer1 and downstream microRNAs. We thus present a foundation for the development of novel therapeutic targets to promote stress resilience. |
