| First Author | Vassilev V | Year | 2017 |
| Journal | Dev Cell | Volume | 43 |
| Issue | 4 | Pages | 463-479.e5 |
| PubMed ID | 29103954 | Mgi Jnum | J:248588 |
| Mgi Id | MGI:6092845 | Doi | 10.1016/j.devcel.2017.10.014 |
| Citation | Vassilev V, et al. (2017) Catenins Steer Cell Migration via Stabilization of Front-Rear Polarity. Dev Cell 43(4):463-479.e5 |
| abstractText | Cell migration plays a pivotal role in morphogenetic and pathogenetic processes. To achieve directional migration, cells must establish a front-to-rear axis of polarity. Here we show that components of the cadherin-catenin complex function to stabilize this front-rear polarity. Neural crest and glioblastoma cells undergo directional migration in vivo or in vitro. During this process, alphaE-catenin accumulated at lamellipodial membranes and then moved toward the rear with the support of a tyrosine-phosphorylated beta-catenin. This relocating alphaE-catenin bound to p115RhoGEF, leading to gathering of active RhoA in front of the nucleus where myosin-IIB arcs assemble. When catenins or p115RhoGEF were removed, cells lost the polarized myosin-IIB assembly, as well as the capability for directional movement. These results suggest that, apart from its well-known function in cell adhesion, the beta-catenin/alphaE-catenin complex regulates directional cell migration by restricting active RhoA to perinuclear regions and controlling myosin-IIB dynamics at these sites. |
