| First Author | Cobas M | Year | 2004 |
| Journal | J Exp Med | Volume | 199 |
| Issue | 2 | Pages | 221-9 |
| PubMed ID | 14718516 | Mgi Jnum | J:89995 |
| Mgi Id | MGI:3042096 | Doi | 10.1084/jem.20031615 |
| Citation | Cobas M, et al. (2004) Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med 199(2):221-9 |
| abstractText | Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis. |
