Other
11 Authors
- Brittain GC,
- Li HS,
- Cheng X,
- Watowich SS,
- Zou Q,
- Sun SC,
- Yu J,
- Hu H,
- Jin J,
- Xiao Y,
- Mallette FA
| First Author | Jin J | Year | 2014 |
| Journal | Immunity | Volume | 40 |
| Issue | 3 | Pages | 342-54 |
| PubMed ID | 24656046 | Mgi Jnum | J:209992 |
| Mgi Id | MGI:5569211 | Doi | 10.1016/j.immuni.2014.02.006 |
| Citation | Jin J, et al. (2014) Noncanonical NF-kappaB pathway controls the production of type I interferons in antiviral innate immunity. Immunity 40(3):342-54 |
| abstractText | Production of type I interferons (IFN-I) is a crucial innate immune mechanism against viral infections. IFN-I induction is subject to negative regulation by both viral and cellular factors, but the underlying mechanism remains unclear. We report that the noncanonical NF-kappaB pathway was stimulated along with innate immune cell differentiation and viral infections and had a vital role in negatively regulating IFN-I induction. Genetic deficiencies in major components of the noncanonical NF-kappaB pathway caused IFN-I hyperinduction and rendered cells and mice substantially more resistant to viral infection. Noncanonical NF-kappaB suppressed signal-induced histone modifications at the Ifnb promoter, an action that involved attenuated recruitment of the transcription factor RelA and a histone demethylase, JMJD2A. These findings reveal an unexpected function of the noncanonical NF-kappaB pathway and highlight an important mechanism regulating antiviral innate immunity. |
