| First Author | Schumacher MA | Year | 2021 |
| Journal | Am J Physiol Gastrointest Liver Physiol | Volume | 320 |
| Issue | 6 | Pages | G990-G1001 |
| PubMed ID | 33826403 | Mgi Jnum | J:351724 |
| Mgi Id | MGI:7666208 | Doi | 10.1152/ajpgi.00296.2020 |
| Citation | Schumacher MA, et al. (2021) NRG4-ErbB4 signaling represses proinflammatory macrophage activity. Am J Physiol Gastrointest Liver Physiol 320(6):G990-G1001 |
| abstractText | Proinflammatory macrophages are essential drivers of colitis and express the growth factor receptor ErbB4. This study tested the role of ErbB4 and its specific ligand, NRG4, in regulating macrophage function. We show that endogenous NRG4-ErbB4 signaling limits macrophage production of proinflammatory cytokines in vitro and limits colitis severity in vivo and thus is a potential target for therapeutic intervention. |
