| First Author | Zhou HY | Year | 2023 |
| Journal | Cell Metab | Volume | 35 |
| Issue | 11 | Pages | 1915-1930.e8 |
| PubMed ID | 37703873 | Mgi Jnum | J:357884 |
| Mgi Id | MGI:7540267 | Doi | 10.1016/j.cmet.2023.08.009 |
| Citation | Zhou HY, et al. (2023) Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain. Cell Metab |
| abstractText | Weight regain after weight loss is a major challenge in the treatment of obesity. Immune cells adapt to fluctuating nutritional stress, but their roles in regulating weight regain remain unclear. Here, we identify a stem cell-like CD7(+) monocyte subpopulation accumulating in the bone marrow (BM) of mice and humans that experienced dieting-induced weight loss. Adoptive transfer of CD7(+) monocytes suppresses weight regain, whereas inducible depletion of CD7(+) monocytes accelerates it. These cells, accumulating metabolic memories via epigenetic adaptations, preferentially migrate to the subcutaneous white adipose tissue (WAT), where they secrete fibrinogen-like protein 2 (FGL2) to activate the protein kinase A (PKA) signaling pathway and facilitate beige fat thermogenesis. Nevertheless, CD7(+) monocytes gradually enter a quiescent state after weight loss, accompanied by increased susceptibility to weight regain. Notably, administration of FMS-like tyrosine kinase 3 ligand (FLT3L) remarkably rejuvenates CD7(+) monocytes, thus ameliorating rapid weight regain. Together, our findings identify a unique bone marrow-derived metabolic-memory immune cell population that could be targeted to combat obesity. |
