| First Author | Gensollen T | Year | 2021 |
| Journal | Nat Immunol | Volume | 22 |
| Issue | 6 | Pages | 699-710 |
| PubMed ID | 34040226 | Mgi Jnum | J:359749 |
| Mgi Id | MGI:6740263 | Doi | 10.1038/s41590-021-00934-0 |
| Citation | Gensollen T, et al. (2021) Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces. Nat Immunol 22(6):699-710 |
| abstractText | It is increasingly recognized that immune development within mucosal tissues is under the control of environmental factors during early life. However, the cellular mechanisms that underlie such temporally and regionally restrictive governance of these processes are unclear. Here, we uncover an extrathymic pathway of immune development within the colon that is controlled by embryonic but not bone marrow-derived macrophages, which determines the ability of these organs to receive invariant natural killer T (iNKT) cells and allow them to establish local residency. Consequently, early-life perturbations of fetal-derived macrophages result in persistent decreases of mucosal iNKT cells and is associated with later-life susceptibility or resistance to iNKT cell-associated mucosal disorders. These studies uncover a host developmental program orchestrated by ontogenically distinct macrophages that is regulated by microbiota, and they reveal an important postnatal function of macrophages that emerge in fetal life. |
